Tysabri Financial Assistance: Copay Cards, Patient Programs, and Free Drug Options
Tysabri (natalizumab) is used to treat relapsing forms of multiple sclerosis and Crohn's disease. The cost can be significant, and that is a real barrier for many people, regardless of whether they have insurance. The good news is that legitimate programs exist to help you afford this medication, and most people who apply find at least one option that fits their situation.
Manufacturer Copay Assistance
If you have commercial (private) insurance, Biogen's Biogen Assist360 Copay Program may be available to you. Copay assistance programs cover a portion or all of your out-of-pocket costs, including your deductible, copay, or coinsurance, depending on the program terms.
To apply, visit https://www.biogenassist360.com or call the support line listed on that page. You will typically need your insurance card, prescription information, and your prescribing doctor's contact details.
Important eligibility note: Manufacturer copay cards are only available to patients with commercial (private or employer-sponsored) insurance. They cannot be used if your coverage comes from a federal or state program including Medicare, Medicaid, TRICARE, or any other government-funded plan. Using a copay card with a government plan violates federal anti-kickback law.Biogen Assist360 may reduce monthly Tysabri costs for eligible commercially insured patients. Note: Tysabri is only available through a REMS program (TOUCH Prescribing Program).
Patient Assistance Programs (Free Drug)
If you are uninsured, underinsured, or on Medicare or Medicaid, a Patient Assistance Program (PAP) may provide Tysabri at no cost or very low cost.
Biogen operates the Biogen Patient Assistance Program, which provides Tysabri free of charge to patients who meet income and insurance eligibility requirements. Most programs require an annual income below a set threshold (often 400% to 600% of the federal poverty level, though this varies), and your prescribing doctor will typically need to submit the application on your behalf.
To apply or learn more, visit https://www.biogenassist360.com.
Independent Foundations
Independent nonprofit foundations provide financial assistance based on condition and income, separate from the manufacturer. These are a good option when you earn too much to qualify for a PAP but still cannot comfortably afford your out-of-pocket costs, or when the copay card does not work with your insurance.
The PAN Foundation (Patient Advocate Network Foundation) provides disease-specific grants to help underinsured patients cover out-of-pocket costs including copays, premiums, and transportation. Funds are limited and open on a rolling basis, so it is worth checking regularly if a disease fund applies to your condition.
The HealthWell Foundation offers financial assistance grants for a wide range of conditions, including many of the diseases treated with this medication. Eligibility is based on income and insurance status.
Good Days is a national nonprofit that provides disease-specific financial assistance for out-of-pocket medication and treatment costs for qualifying patients. NeedyMeds maintains a free database of patient assistance programs, copay cards, and disease-specific foundations. You can search by drug name or condition to find options you may not have heard of.The National Organization for Rare Disorders (NORD) provides patient assistance programs for some of the rarer conditions treated with this drug. If you have a rare diagnosis, NORD's assistance fund may be available.
What if Your Insurance Denied Tysabri?
Tysabri requires REMS enrollment and is frequently subject to step therapy requirements. Re-authorizations may be denied if monitoring documentation is missing. A denial is not always the final word. You have the right to appeal, and many denials are overturned with the right documentation.
Ellen can help you understand your denial and build your appeal. Start here →
For more on your options after a Tysabri denial, including clinical trial pathways, see our complete Tysabri denial guide.
Frequently Asked Questions
Does Tysabri have a copay card?
Yes. Biogen's Biogen Assist360 Copay Program is available to patients with commercial (private) insurance. Eligibility requirements and savings amounts vary by program. You can apply at https://www.biogenassist360.com or by calling the program's support line.
Can I get Tysabri for free?
Possibly. Biogen operates the Biogen Patient Assistance Program, which provides Tysabri at no cost to qualifying patients who are uninsured, underinsured, or cannot afford their medication even with insurance. Income-based eligibility typically applies. Independent foundations such as the PAN Foundation and HealthWell Foundation may also help cover costs.
What if I am on Medicare?
Copay programs cannot be used with Medicare. Biogen offers a separate patient assistance program for qualifying uninsured or Medicare patients.
Last updated: March 2026. Program details change. Always confirm eligibility and availability directly with the manufacturer or foundation before applying.