Enhertu Financial Assistance: Copay Cards, Patient Programs, and Free Drug Options
Enhertu (fam-trastuzumab deruxtecan) is used to treat HER2-positive and HER2-low breast cancer, HER2-positive gastric cancer, and HER2-mutant non-small cell lung cancer. The cost can be significant, and that is a real barrier for many people, regardless of whether they have insurance. The good news is that legitimate programs exist to help you afford this medication, and most people who apply find at least one option that fits their situation.
Manufacturer Copay Assistance
If you have commercial (private) insurance, AstraZeneca and Daiichi Sankyo's Enhertu Copay Assistance Program may be available to you. Copay assistance programs cover a portion or all of your out-of-pocket costs, including your deductible, copay, or coinsurance, depending on the program terms.
To apply, visit https://www.azandme.com or call the support line listed on that page. You will typically need your insurance card, prescription information, and your prescribing doctor's contact details.
Important eligibility note: Manufacturer copay cards are only available to patients with commercial (private or employer-sponsored) insurance. They cannot be used if your coverage comes from a federal or state program including Medicare, Medicaid, TRICARE, or any other government-funded plan. Using a copay card with a government plan violates federal anti-kickback law.AstraZeneca's AZ&Me program may offer copay support for eligible commercially insured Enhertu patients.
Patient Assistance Programs (Free Drug)
If you are uninsured, underinsured, or on Medicare or Medicaid, a Patient Assistance Program (PAP) may provide Enhertu at no cost or very low cost.
AstraZeneca and Daiichi Sankyo operates the AZ&Me / Daiichi Sankyo Patient Support, which provides Enhertu free of charge to patients who meet income and insurance eligibility requirements. Most programs require an annual income below a set threshold (often 400% to 600% of the federal poverty level, though this varies), and your prescribing doctor will typically need to submit the application on your behalf.
To apply or learn more, visit https://www.azandme.com.
Independent Foundations
Independent nonprofit foundations provide financial assistance based on condition and income, separate from the manufacturer. These are a good option when you earn too much to qualify for a PAP but still cannot comfortably afford your out-of-pocket costs, or when the copay card does not work with your insurance.
The PAN Foundation (Patient Advocate Network Foundation) provides disease-specific grants to help underinsured patients cover out-of-pocket costs including copays, premiums, and transportation. Funds are limited and open on a rolling basis, so it is worth checking regularly if a disease fund applies to your condition.
The HealthWell Foundation offers financial assistance grants for a wide range of conditions, including many of the diseases treated with this medication. Eligibility is based on income and insurance status.
Good Days is a national nonprofit that provides disease-specific financial assistance for out-of-pocket medication and treatment costs for qualifying patients. NeedyMeds maintains a free database of patient assistance programs, copay cards, and disease-specific foundations. You can search by drug name or condition to find options you may not have heard of.What if Your Insurance Denied Enhertu?
Enhertu may be denied when HER2 testing or prior treatment documentation is incomplete, or for HER2-low indications where local coverage policies differ. A denial is not always the final word. You have the right to appeal, and many denials are overturned with the right documentation.
Ellen can help you understand your denial and build your appeal. Start here →
Frequently Asked Questions
Does Enhertu have a copay card?
Yes. AstraZeneca and Daiichi Sankyo's Enhertu Copay Assistance Program is available to patients with commercial (private) insurance. Eligibility requirements and savings amounts vary by program. You can apply at https://www.azandme.com or by calling the program's support line.
Can I get Enhertu for free?
Possibly. AstraZeneca and Daiichi Sankyo operates the AZ&Me / Daiichi Sankyo Patient Support, which provides Enhertu at no cost to qualifying patients who are uninsured, underinsured, or cannot afford their medication even with insurance. Income-based eligibility typically applies. Independent foundations such as the PAN Foundation and HealthWell Foundation may also help cover costs.
What if I am on Medicare?
Copay programs are unavailable to Medicare patients. AZ&Me also includes free drug options for qualifying patients.
Last updated: March 2026. Program details change. Always confirm eligibility and availability directly with the manufacturer or foundation before applying.