ra biologics comparison

Most prescribed biologic for RA; extensive data; biosimilars available

TNF receptor fusion protein; different mechanism than monoclonal antibody TNFi

T-cell costimulation modulator; different mechanism than TNF inhibitors

IL-6 receptor antagonist; effective as monotherapy (without methotrexate)

JAK inhibitor; oral; black-box warning limits to post-biologic failure

First oral JAK inhibitor for RA; black-box warning

PEGylated TNFi; no active placental transfer (preferred in pregnancy)

IV TNFi; biosimilars widely available and often preferred by payers